499142-35-7Relevant academic research and scientific papers
Combined theoretical and experimental studies reveal the newly synthesized pyrimidinones as potential apoptotic agents
Dar, Ayaz Mahmood,Mir, Shafia,Jan, Masrat,Nabi, Rizwan,Gatoo, Manzoor Ahmad,Shamsuzzaman
, (2021)
Reaction of acetophenone thiosemicarbazones (5–8) and (2-methyl) diethyl malonate in absolute ethanol under reflux conditions furnished the corresponding pyrimidinone analogs (9–12) in good to excellent yields. The resulting pyrimidines were characterised
Design, synthesis, bioactivity, and DFT calculation of 2-thiazolyl-hydrazone derivatives as influenza neuraminidase inhibitors
Cui, Man-Ying,Nie, Jian-Xia,Yan, Zhong-Zhong,Xiao, Meng-Wu,Lin, Ding,Ye, Jiao,Hu, Ai-Xi
, p. 938 - 947 (2019/05/15)
Three series of thiazolylhydrazone derivatives were designed, synthesized, and evaluated for their neuraminidase (NA) inhibitory activity against influenza virus H1N1 in vitro. Compounds 1 and 2 were synthesized via the one-pot reaction and compound 3 was
(4-alkyl-5-acyl-2-thiazole) hydrazone derivatives and medical application thereof
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Paragraph 0044-0048, (2018/09/28)
The invention relates to (4-alkyl-5-acyl-2-thiazole) hydrazone derivatives shown as a formula I and pharmaceutically acceptable salts thereof, a medicinal composition and the application thereof to preparation of an influenza virus neuraminidase inhibitor
M-STAGE KINESIN INHIBITOR
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Page/Page column 74, (2010/11/08)
A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein R1 represents a hydrogen atom and the like, R2 represents a hydrogen atom, -C(=W)R6 (wherein W represents an oxygen atom or a sulfur atom, and R6 represents substituted or unsubstituted lower alkyl and the like) and the like, R3 represents -C(=Z)R19 (wherein Z represents an oxygen atom or a sulfur atom, and R19 represents substituted or unsubstituted lower alkyl and the like) and the like, R4 represents substituted or unsubstituted lower alkyl and the like, and R5 represents substituted or unsubstituted aryl and the like] and the like are provided.
THIADIAZOLINE DERIVATIVE
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Page 49, (2010/02/08)
(wherein R1 and R4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R5 represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R2 represents -C(-W)R6 or the like; R3 represents a hydrogen atom, -C(=WA)R6A, or the like) Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided.
