499152-52-2Relevant academic research and scientific papers
Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists
Asada, Masaki,Obitsu, Tetsuo,Kinoshita, Atsushi,Nakai, Yoshihiko,Nagase, Toshihiko,Sugimoto, Isamu,Tanaka, Motoyuki,Takizawa, Hiroya,Yoshikawa, Ken,Sato, Kazutoyo,Narita, Masami,Ohuchida, Shuichi,Nakai, Hisao,Toda, Masaaki
scheme or table, p. 2639 - 2643 (2010/07/05)
A series of novel N-acylsulfonamide analogs were synthesized and evaluated for their binding affinity and antagonist activity for the EP3 receptor subtype. Representative compounds were also evaluated for their inhibitory effect on PGE2-induced
CARBOXYLIC ACID DERIVATIVE COMPOUNDS AND DRUGS COMPRISING THESE COMPOUNDS AS THE ACTIVE INGREDIENT
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Page 449, (2010/02/07)
A carboxylic acid derivative of formula (I): wherein R1 is-COOH,-COOR6, etc.; A is a single bond, alkylene, etc.; R2 is alkyl, alkoxy, etc.; B is a carbocyclic ring or a heterocyclic ring; Q is alkylnene-Cyc2, etc.; D is a linking chain; and R3 is alkyl,
