499157-70-9

Basic information

• Product Name: N-benzyloxy-N-(3-methyl-1-(3,5-dimethylphenyl)butyl)amine
• Synonyms: N-benzyloxy-N-(3-methyl-1-(3,5-dimethylphenyl)butyl)amine
• CAS NO: 499157-70-9
• Molecular Weight: 297.44
• Mol File: 499157-70-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-benzyloxy-N-(3-methyl-1-(3,5-dimethylphenyl)butyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyloxy-N-(3-methyl-1-(3,5-dimethylphenyl)butyl)amine(499157-70-9)
• EPA Substance Registry System: N-benzyloxy-N-(3-methyl-1-(3,5-dimethylphenyl)butyl)amine(499157-70-9)

Safety Data

• Hazardous Substances Data: 499157-70-9(Hazardous Substances Data)

Upstream product

• 590-86-3 isovaleraldehyde 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 72399-25-8 3-methylbutyraldehyde O-benzyl-oxime 
• 556-96-7 5-bromo-1,3-xylene 

Downstream Products

• 499154-46-0 3-(2-((3-methyl-1-(3,5-dimethylphenyl)butyl)carbamoyl)-4-methoxymethoxyphenyl)propanoic acid methyl ester 
• 784135-46-2 1-(3,5-dimethylphenyl)-3-methylbutan-1-amine 
• 499157-72-1 1-(3,5-dimethylphenyl)-3-methylbutan-1-amine hydrochloride 

Relevant articles and documents

3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 2: Optimization of the side chains to improve in vitro and in vivo potencies

A series of 3-[2-{[(3-methyl-1-phenylbutyl)amino]carbonyl}-4-(phenoxymethyl)phenyl]propanoic acid analogs were synthesized and evaluated for their in vitro potency. In most cases, introduction of one or two substituents into the two phenyl moieties resulted in the tendency of an increase or retention of in vitro activities. Several compounds, which showed excellent subtype selectivity, were evaluated for their inhibitory effect against PGE2-induced uterine contraction in pregnant rats, which is thought to be mediated by the EP3 receptor subtype. The structure-activity relationships (SARs) are also discussed.