499183-95-8Relevant academic research and scientific papers
Dehydrosulfurative C-N Cross-Coupling and Concomitant Oxidative Dehydrogenation for One-Step Synthesis of 2-Aryl(alkyl)aminopyrimidines from 3,4-Dihydropyrimidin-1H-2-thiones
Phan, Nguyen Huu Trong,Kim, Hyeji,Shin, Hyunik,Lee, Hee-Seung,Sohn, Jeong-Hun
, p. 5154 - 5157 (2016)
A method for the synthesis of 2-aryl(alkyl)aminopyrimidines from readily available 3,4-dihydropyrimidin-1H-2-thiones (DHPMs) via dehydrosulfurative C-N cross-coupling and concomitant oxidative dehydrogenation under a Pd/Cu catalytic system is described. This reaction protocol provides unprecedented diversity of fully substituted 2-aryl(alkyl)aminopyrimidines in a single step from a wide range of DHPMs and amine coupling partners.
Microwave-assisted and iodine-catalyzed synthesis of dihydropyrimidin-2- thiones via Biginelli reaction under solvent-free conditions
Liu, Qingjian,Pan, Ning,Xu, Jiehua,Zhang, Wenwen,Kong, Fanpeng
, p. 139 - 146 (2012/11/07)
Microwave-assisted synthesis of 3,4-dihydropyrimidin-2-thiones via Biginelli reaction from aldehydes, acetoacetates, and thiourea in the presence of iodine under solvent-free conditions has been accomplished in good yields and purity without chromatograph
