499201-99-9Relevant academic research and scientific papers
Stereoselective reductase-catalysed deoxygenation of sulfoxides in aerobic and anaerobic bacteria.
Boyd, Derek R,Sharma, Narain D,King, Alistair W T,Shepherd, Steven D,Allen, Christopher C R,Holt, Robert A,Luckarift, Heather R,Dalton, Howard
, p. 554 - 561 (2004)
Direct and indirect evidence, of unexpected stereoselective reductase-catalysed deoxygenations of sulfoxides, was found. The deoxygenations proceeded simultaneously, with the expected dioxygenase-catalysed asymmetric sulfoxidation of sulfides, during some biotransformations with the aerobic bacterium Pseudomonas putida UV4. Stereoselective reductase-catalysed asymmetric deoxygenation of racemic alkylaryl, dialkyl and phenolic sulfoxides was observed, without evidence of the reverse sulfoxidation reaction, using anaerobic bacterial strains. A purified dimethyl sulfoxide reductase, obtained from the intact cells of the anaerobic bacterium Citrobacter braakii DMSO 11, yielded, from the corresponding racemates, enantiopure alkylaryl sulfoxide and thiosulfinate samples.
