499202-76-5Relevant academic research and scientific papers
Copper-catalyzed amidations of bromo substituted furans and thiophenes
Crawford, Kenneth R,Padwa, Albert
, p. 7365 - 7368 (2007/10/03)
The C-N cross-coupling reaction between aromatic halides and amides has now been applied to 2- and 3-substituted bromofurans and bromothiophenes. Catalytic CuI in the presence of N,N′-dimethylethylenediamine as a ligand and K3PO4 or K2CO3 as the base furnished 2- and 3-substituted amidofurans and thiophenes ranging from 11 to 99% depending on the particular amide source used.
