4994-89-2

Usage

Uses

Used in Pharmaceutical Industry:
5,6-DIMETHYL-THIENO[2,3-D]PYRIMIDIN-4-YLAMINE is used as a pharmaceutical intermediate for the synthesis of various drugs and pharmaceutical compounds. Its role in this industry is crucial as it aids in the development of new medications for a range of therapeutic indications. 5,6-DIMETHYL-THIENO[2,3-D]PYRIMIDIN-4-YLAMINE's specific properties and uses are tailored to the particular applications and formulations in which it is incorporated, highlighting its versatility and importance in medicinal chemistry.

InChI:InChI=1/C8H9N3S/c1-4-5(2)12-8-6(4)7(9)10-3-11-8/h3H,1-2H3,(H2,9,10,11)

Upstream product

• 4651-94-9 2-amino-4,5-dimethylthiophene-3-carbonitrile 
• 122-51-0 orthoformic acid triethyl ester 
• 77287-34-4 formamide 
• 4815-24-1 2-amino-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester 
• 18593-44-7 5,6-dimethylthieno<2,3-d>pyrimidin-4(3H)-one 

Downstream Products

• 200343-04-0 (5,6-Dimethyl-thieno[2,3-d]pyrimidin-4-yl)-(4-methoxy-phenyl)-acetonitrile 

Relevant academic research and scientific papers

Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors

4-Aminobenzothieno[3,2-d]pyrimidines were previously identified in a high throughput screening campaign as LIMK1 inhibitors. Scaffold reversal led to the identification of a series of simple 5,6-substituted 4-aminothieno[2,3-d] pyrimidines with low micromolar inhibition of LIMK1.

MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH

The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

Synthesis and anti-microbial activity of some heterocycles: Part-II

Thieno[2,3-d]pyrimidines (2), (3) and (4) have been obtained via the reaction of 2-amino-4, 5-dimethylthiophen-3-carbonitrile (1) with formamide, acetonitrile and benzonitrile respectively. Treatment of (2), (3) and (4) with chloroacetaldehyde respectivel