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499770-73-9

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499770-73-9 Usage

General Description

4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBONYL CHLORIDE is a chemical compound that belongs to the benzoxazine class of compounds. It is a carbonyl chloride derivative, and it is commonly used in organic synthesis and pharmaceutical research. 4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBONYL CHLORIDE is known for its reactivity as a carbonyl chloride, making it a valuable intermediate in the production of various organic compounds. Its unique structure and reactivity make it a useful building block for the synthesis of diverse chemical molecules. Additionally, it has potential applications in the development of new drugs and materials.

Check Digit Verification of cas no

The CAS Registry Mumber 499770-73-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,9,7,7 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 499770-73:
(8*4)+(7*9)+(6*9)+(5*7)+(4*7)+(3*0)+(2*7)+(1*3)=229
229 % 10 = 9
So 499770-73-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H10ClNO2/c1-12-4-5-14-9-6-7(10(11)13)2-3-8(9)12/h2-3,6H,4-5H2,1H3

499770-73-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-methyl-2,3-dihydro-1,4-benzoxazine-7-carbonyl chloride

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:499770-73-9 SDS

499770-73-9Downstream Products

499770-73-9Relevant articles and documents

Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus

Eissa, Ibrahim H.,Mohammad, Haroon,Qassem, Omar A.,Younis, Waleed,Abdelghany, Tamer M.,Elshafeey, Ahmed,Abd Rabo Moustafa, Mahmoud M.,Seleem, Mohamed N.,Mayhoub, Abdelrahman S.

, p. 73 - 85 (2017)

A new class of diphenylurea was identified as a novel antibacterial scaffold with an antibacterial spectrum that includes highly resistant staphylococcal isolates, namely methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA & VRSA). Starting with a lead compound 3 that carries an aminoguanidine functionality from one side and a n-butyl moiety on the other ring, several analogues were prepared. Considering the pharmacokinetic parameters as a key factor in structural optimization, the structure-activity-relationships (SARs) at the lipophilic side chain were rigorously examined leading to the discovery of the cycloheptyloxyl analogue 21n as a potential drug-candidate. This compound has several notable advantages over vancomycin and linezolid including rapid killing kinetics against MRSA and the ability to target and reduce the burden of MRSA harboring inside immune cells (macrophages). Furthermore, the potent anti-MRSA activity of 21n was confirmed in?vivo using a Caenorhabditis elegans animal model. The present study provides a foundation for further development of diphenylurea compounds as potential therapeutic agents to address the burgeoning challenge of bacterial resistance to antibiotics.

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