499774-45-7

Basic information

• Product Name: (3R)-2,2,2-TRIFLUORO-N-PYRROLIDIN-3-YL-ACETAMIDE
• Synonyms: (3R)-2,2,2-TRIFLUORO-N-PYRROLIDIN-3-YL-ACETAMIDE;(R)-2,2,2-TRIFLUORO-N-(PYRROLIDIN-3-YL)ETHANAMIDE;2,2,2-trifluoro-N-[(3R)-pyrrolidin-3-yl]acetamide
• CAS NO: 499774-45-7
• Molecular Formula: C₆H₉F₃N₂O
• Molecular Weight: 182.14
• Mol File: 499774-45-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3R)-2,2,2-TRIFLUORO-N-PYRROLIDIN-3-YL-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-2,2,2-TRIFLUORO-N-PYRROLIDIN-3-YL-ACETAMIDE(499774-45-7)
• EPA Substance Registry System: (3R)-2,2,2-TRIFLUORO-N-PYRROLIDIN-3-YL-ACETAMIDE(499774-45-7)

Safety Data

• Hazardous Substances Data: 499774-45-7(Hazardous Substances Data)

Upstream product

• 400045-36-5 N-(1-benzyl-pyrrolidin-3-yl)-2,2,2-trifluoro-acetamide 

Downstream Products

• 917354-56-4 4'-Trifluoromethyl-biphenyl-4-carboxylic acid methyl-{(S)-1-[(R)-3-(2,2,2-trifluoro-acetylamino)-pyrrolidine-1-carbonyl]-pyrrolidin-3-yl}-amide 
• 764722-67-0 5-(4-Trifluoromethyl-phenyl)-thiophene-2-carboxylic acid methyl-{(S)-1-[(R)-3-(2,2,2-trifluoro-acetylamino)-pyrrolidine-1-carbonyl]-pyrrolidin-3-yl}-amide 
• 917354-58-6 5-(4-Methoxy-2-methyl-phenyl)-thiophene-2-carboxylic acid methyl-{(S)-1-[(R)-3-(2,2,2-trifluoro-acetylamino)-pyrrolidine-1-carbonyl]-pyrrolidin-3-yl}-amide 
• 917354-59-7 5-(4-Ethyl-phenyl)-thiophene-2-carboxylic acid methyl-{(S)-1-[(R)-3-(2,2,2-trifluoro-acetylamino)-pyrrolidine-1-carbonyl]-pyrrolidin-3-yl}-amide 
• 917358-16-8 5-(4-Ethyl-phenyl)-thiophene-2-carboxylic acid methyl-((S)-1-{(R)-3-[methyl-(2,2,2-trifluoro-acetyl)-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl)-amide 
• 917353-86-7 4'-Ethyl-biphenyl-4-carboxylic acid methyl-{(S)-1-[(R)-3-(2,2,2-trifluoro-acetylamino)-pyrrolidine-1-carbonyl]-pyrrolidin-3-yl}-amide 

Relevant articles and documents

Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2

The design, synthesis, and SAR of a series of retro bis-aminopyrrolidine ureas are described. Compounds from this series exhibited considerable binding affinity (Ki = 1 nM) and functional activity at MCH-R1, acceptable CYP2D6 inhibition, and good rat brain exposure.