499784-05-3

Upstream product

• 499783-98-1 4-methylthiophenacyl 3-methoxyphenylacetate 
• 42445-46-5 2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone 
• 100-68-5 methyl-phenyl-thioether 
• 1778-09-2 4-(Methylthio)acetophenone 
• 499784-02-0 3-(3-methoxyphenyl)-4-(4-methylthiophenyl)-2(5H)furanone 

Downstream Products

• 499784-08-6 acetic acid 3-[4-(4-methylsulfanyl-phenyl)-2-oxo-2,5-dihydro-furan-3-yl]-phenyl ester 

Relevant academic research and scientific papers

Isomeric acetoxy analogues of rofecoxib: A novel class of highly potent and selective cyclooxygenase-2 inhibitors

A group of isomers possessing a 2-, 3-, or 4-acetoxy moiety on the 3-phenyl substituent of rofecoxib were synthesized that exhibit highly potent, and selective, COX-2 inhibitory activity that have the potential to acetylate the COX-2 isozyme.