499787-31-4Relevant articles and documents
Synthesis of functionalised pyrido[4,3-b][1,4]oxazine and imidazo[1,2-a]pyridine derivatives
Arrault, Axelle,Touzeau, Frédérique,Guillaumet, Gérald,Léger, Jean-Michel,Jarry, Christian,Mérour, Jean-Yves
, p. 8145 - 8152 (2007/10/03)
Ethyl 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-2-carboxylate derivatives were obtained from 3-hydroxy-2-aminopyridine and ethyl 2,3-dibromopropanoate. Reduction of thiolactam 17 obtained from the lactam 9 gave the corresponding ethyl 2H-pyrido[3,2-b][1,4]oxazine-2-carboxylate. The use of ethyl 2-chloro-3-oxopropanoate with 2-amino-3-hydroxypyridine or 3-amino-4-hydroxypyridine led, respectively, to imidazo[1,2-a]pyridine derivatives or ethyl pyrido[4,3-b][1,4] oxazine-2-carboxylate.