4999-02-4

Upstream product

• 15898-43-8 sodium 4-acetamidobenzenesulfinate 
• 78-95-5 chloroacetone 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 

Downstream Products

• 792915-59-4 acetic acid-[4-(2-amino-4-methyl-thiazole-5-sulfonyl)-anilide] 
• 57946-90-4 2-bromo-4-methanesulfonylphenylamine 
• 861061-00-9 acetic acid-[2-bromo-4-(2-oxo-propane-1-sulfonyl)-anilide] 
• 861061-01-0 acetic acid-[N-bromo-4-(2-oxo-propane-1-sulfonyl)-anilide] 
• 792915-41-4 acetic acid-[4-(1-bromo-2-oxo-propane-1-sulfonyl)-anilide] 

Relevant academic research and scientific papers

Facile One-Pot Access to α-Diazo-β-ketosulfones from Sulfonyl Chlorides and α-Haloketones

A convenient one-pot approach to the preparation of α-diazo-β-ketosulfones from sulfonyl chlorides is described. It involves the conversion of the sulfonyl chloride to sodium sulfinate, alkylation of the latter with α-haloketones followed by diazo transfer using the 'sulfonyl-azide-free' ('SAFE') protocol in aqueous medium. The simple and expedient method relies on readily available starting materials and provides facile access to a wide variety of valuable diazo reagents for organic synthesis.