499991-81-0Relevant academic research and scientific papers
Discovery, synthesis and biological evaluation of novel glucokinase activators
McKerrecher, Darren,Allen, Joanne V.,Bowker, Suzanne S.,Boyd, Scott,Caulkett, Peter W. R.,Currie, Gordon S.,Davies, Christopher D.,Fenwick, Mark L.,Gaskin, Harold,Grange, Emma,Hargreaves, Rod B.,Hayter, Barry R.,James, Roger,Johnson, Keith M.,Johnstone, Craig,Jones, Clifford D.,Lackie, Sarah,Rayner, John W.,Walker, Rolf P.
, p. 2103 - 2106 (2007/10/03)
The identification, synthesis and SAR of a novel series of glucokinase activators is described. The interplay between lipophilicity, potency and physical properties is discussed, and compound 22 highlighted as having a suitable balance. In vivo pharmacoki
