500-76-5

Basic information

• Product Name: 4-(4-HYDROXYPHENOXY)BENZOIC ACID
• Synonyms: 4-(p-Hydroxyphenoxy)benzoic acid;4-(4-HYDROXYPHENOXY)BENZOIC ACID;4-(4-HYDROXYPHENOXY)BENZOIC ACID 99+%
• CAS NO: 500-76-5
• Molecular Formula: C₁₃H₁₀O₄
• Molecular Weight: 230.22
• Product Categories: Functional Materials;Phenols (Building Blocks for Liquid Crystals);Benzoic Acids (Building Blocks for Liquid Crystals);Bifunctional Compounds (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals
• Mol File: 500-76-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 196°C
• Boiling Point: 427.8°C at 760 mmHg
• Flash Point: 168.6°C
• Appearance: /
• Density: 1.346g/cm³
• Vapor Pressure: 4.43E-08mmHg at 25°C
• Refractive Index: 1.638
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: almost transparency in Methanol
• PKA: 4.39±0.10(Predicted)
• CAS DataBase Reference: 4-(4-HYDROXYPHENOXY)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-HYDROXYPHENOXY)BENZOIC ACID(500-76-5)
• EPA Substance Registry System: 4-(4-HYDROXYPHENOXY)BENZOIC ACID(500-76-5)

Safety Data

• Statements: 36/37/38-43
• Safety Statements: 26-36/37/39-36/37
• Hazardous Substances Data: 500-76-5(Hazardous Substances Data)

Usage

General Description

4-(4-Hydroxyphenoxy)benzoic acid is a chemical compound with the molecular formula C13H10O5. It is a white solid that is insoluble in water but soluble in organic solvents. 4-(4-HYDROXYPHENOXY)BENZOIC ACID is commonly used in the production of pharmaceutical drugs, as well as in the synthesis of dyes and pigments. It is also used as a chemical intermediate in the manufacture of various other organic compounds. 4-(4-Hydroxyphenoxy)benzoic acid has potential applications in various industries due to its versatile chemical properties and is a valuable building block for the synthesis of other compounds.

InChI:InChI=1/C13H10O4/c14-10-3-7-12(8-4-10)17-11-5-1-9(2-6-11)13(15)16/h1-8,14H,(H,15,16)

Upstream product

• 78725-47-0 4-(4-methoxyphenoxy)benzaldehyde 
• 150-76-5 4-methoxy-phenol 
• 459-57-4 4-fluorobenzaldehyde 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 3525-22-2 4'-(4-methoxyphenoxy)benzoic acid 
• 620632-58-8 benzyl 4-(4-benzyloxyphenoxy)benzoate 

Downstream Products

• 1257087-18-5 cyanomethyl (11β,17α)-17-{[4-(4-acetoxyphenoxy)benzoyl]oxy}-9-fluoro-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate 
• 1436378-63-0 N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]-methyl}-2-methylpropyl-4-(4-hydroxyphenoxy)benzamide 
• 1257087-17-4 (11β,17α)-17-{[4-(4-acetoxyphenoxy)benzoyl]oxy}-9-fIuoro-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic acid 
• 131802-89-6 methyl 4-(4-hydroxyphenoxy)benzoate 
• 262447-07-4 N-(4-{[Amino(2-thienyl)methylidene]amino}phenethyl)-4-(4-hydroxyphenoxy)benzamide Hydrochloride 
• 620633-68-3 (S)-4-(4-hydroxyphenoxy)benzoic acid (N-2-hydroxy-1-phenylethyl)amide 

Relevant articles and documents

Selective cleavage of aryl methyl ether moiety of aryloxy aryl methyl ether by 48% HBr/tetra-n-butylphosphonium bromide

Aryl methyl ether moiety in the molecule containing aryl aryl ether part along with aryl methyl ether part is selectively cleaved to give the desired substituted phenol in excellent yield by using 48% HBr in the presence of tetra-n-butylphosphonium bromid

Discovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2- methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonists

There is continuing interest in the discovery and development of new κ opioid receptor antagonists. We recently reported that N-substituted 3-methyl-4-(3-hydroxyphenyl)piperazines were a new class of opioid receptor antagonists. In this study, we report the syntheses of two piperazine JDTic-like analogues. Evaluation of the two compounds in an in vitro [35S] GTPγS binding assay showed that neither compound showed the high potency and κ opioid receptor selectivity of JDTic. A library of compounds using the core scaffold 21 was synthesized and tested for their ability to inhibit [35S]GTPγS binding stimulated by the selective κ opioid agonist U69,593. These studies led to N-[(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3- methylpiperazin-1-yl]methyl}-2-methylpropyl]-4-phenoxybenzamide (11a), a compound that showed good κ opioid receptor antagonist properties. An SAR study based on 11a provided 28 novel analogues. Evaluation of these 28 compounds in the [35S]GTPγS binding assay showed that several of the analogues were potent and selective κ opioid receptor antagonists.

Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors

The present invention relates to triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione; metalloproteinase inhibitors of the formula wherein X, A, Y, B, G, W, and R1 are as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.