5000-88-4Relevant academic research and scientific papers
A formal total synthesis of the marine alkaloid aaptamine
Larghi, Enrique L.,Obrist, Blaise V.,Kaufman, Teodoro S.
, p. 5236 - 5245 (2008)
A new strategy for the synthesis of benzo[de][1,6]naphthyridine derivative 2,3,3a,4,5,6-hexahydroaaptamine, which involves the construction of the isoquinoline ring after elaboration of the quinoline moiety, is described. Since 2,3,3a,4,5,6-hexahydroaaptamine has been previously synthesized as a key intermediate en route to the marine alkaloid aaptamine, access to this compound represents a formal total synthesis of the natural product.
