500015-20-3

Usage

General Description

2-((3-(3, 6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)amino)-2-(hydroxymethyl)propane-1, 3-diol, also known as Adefovir dipivoxil, is a nucleotide analog that is used as a treatment for hepatitis B virus (HBV) infection. This chemical compound works by inhibiting the replication of HBV DNA, thereby reducing the viral load in the body. It is administered orally and is converted to its active form, adefovir, in the body. Adefovir dipivoxil has shown efficacy in suppressing HBV replication and improving liver function in patients with chronic hepatitis B. However, it may cause side effects such as kidney toxicity and bone loss, so it is important for patients to be monitored closely while taking this medication.

Upstream product

• 5599-71-3 3,6-dichloro-9H-carbazole 
• 65679-71-2 3,6-dichloro-9-(oxiran-2-ylmethyl)-9H-carbazole 
• 77-86-1 2-amino-2-hydroxymethyl-1,3-propanediol 

Relevant academic research and scientific papers

Membrane-targeting dcap analogues with broad-spectrum antibiotic activity against pathogenic bacteria

We performed a structure-activity relationship study of 2-((3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)amino)-2-(hydroxymethyl)propane-1,3-diol (DCAP), which is an antibacterial agent that disrupts the membrane potential and permeability of bacteri

ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF

Described herein are antimicrobial compounds identified via a high-throughput inhibitor screen of the in vitro activity of MipZ, which is an ATPase that regulates division site placement in Caulobacter crescentus. The compounds and their analogs are active against bacterial membranes and thus represent a novel class of antimicrobial compounds. The antimicrobial compounds are effective against both actively growing bacterial cells as well as bacterial cells in the stationary phase. The antimicrobial compounds are also effective against bacteria in biofilms.