500019-46-5Relevant academic research and scientific papers
Easily accessible TADDOL-derived bisphosphonite ligands: Synthesis and application in the asymmetric hydroformylation of vinylarenes
Allmendinger, Simon,Kinuta, Hirotaka,Breit, Bernhard
supporting information, p. 41 - 45 (2015/03/03)
The synthesis of chiral bidentate bisphosphonite ligands based on the TADDOL motif from readily available starting materials has been developed. Taking advantage of the modular nature of the building blocks, a diverse ligand library has been prepared. Their catalytic potential has been evaluated in the asymmetric hydroformylation of styrene and derivatives. These catalysts showed high activity and provided the aldehydes in high enantiomeric purity.
Highly regio- and enantioselective catalytic asymmetric hydroboration of α-substituted styrenyl derivatives
Mazet, Clement,Gerard, David
supporting information; experimental part, p. 298 - 300 (2011/02/24)
The catalytic asymmetric hydroboration of a variety of 1,1-disubstituted olefins has been achieved with excellent yields, perfect regioselectivity and in some cases, high levels of enantioselectivity using readily accessible iridium catalyst.
NHC-Cu-catalyzed enantioselective hydroboration of acyclic and exocyclic 1,1-disubstituted aryl alkenes
Corberan, Rosa,Mszar, Nicholas W.,Hoveyda, Amir H.
supporting information; experimental part, p. 7079 - 7082 (2011/09/30)
Tough nut to crack: Chiral bidentate N-heterocyclic carbene copper complexes were designed that promote enantioselective hydroborations of one of the most difficult substrate classes: acyclic and exocyclic 1,1-disubstituted alkenes undergo reaction with >98% site selectivity, in up to >98% yield and e.r=96.5:3.5 (see scheme, B2(pin)2 = bis(pinacolato)diboron). Copyright
