500024-85-1

Basic information

• Product Name: 1H-Pyrrole-2-carboximidamide,N-hydroxy-
• Synonyms: 1H-Pyrrole-2-carboximidamide,N-hydroxy-;1H-Pyrrole-2-carboximidamide,N-hydroxy-(9CI)
• CAS NO: 500024-85-1
• Molecular Formula: C₅H₇N₃O
• Molecular Weight: 125.12858
• Product Categories: PYRROLE
• Mol File: 500024-85-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrole-2-carboximidamide,N-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carboximidamide,N-hydroxy-(500024-85-1)
• EPA Substance Registry System: 1H-Pyrrole-2-carboximidamide,N-hydroxy-(500024-85-1)

Safety Data

• Hazardous Substances Data: 500024-85-1(Hazardous Substances Data)

Usage

Structure

A five-membered aromatic ring containing one nitrogen atom, with an N-hydroxy group and a carboximidamide functional group.

Type

A derivative of pyrrole

Classification

Hydroxamic acid

Applications

+ Chelating metal ions
+ Inhibiting histone deacetylases
+ Pharmaceutical agent (potential use in cancer treatment and other diseases)
+ Coordination chemistry
+ Catalyst in organic synthesis

Upstream product

• 4513-94-4 1H-pyrrole-2-carbonitrile 

Downstream Products

• 915229-32-2 {3,3-difluoro-5-[3-(1H-pyrrol-2-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone 
• 915229-31-1 (4-fluoro-phenyl)-{3-fluoro-3-[3-(1H-pyrrol-2-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-methanone 

Relevant articles and documents

Synthesis of 2,4-Disubstituted Imidazoles via Nucleophilic Catalysis

A convergent, microwave-assisted protocol for the synthesis of disubstituted NH-imidazoles via nucleophilic catalysis is described. The substituted imidazoles are accessed via the intramolecular addition of a variety of amidoxime substrates to activated a

3,5-Disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof

Disclosed are 3,5-disubstituted-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, R2, A, B and D are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.