500025-30-9

Basic information

• Product Name: 3-(3-THIEN-3-YL-1,2,4-OXADIAZOL-5-YL)PROPANOIC ACID
• Synonyms: 3-(3-THIEN-3-YL-1,2,4-OXADIAZOL-5-YL)PROPANOIC ACID;3-(3-thiophen-3-yl-1,2,4-oxadiazol-5-yl)propanoic acid
• CAS NO: 500025-30-9
• Molecular Formula: C9H8N2O3S
• Molecular Weight: 224.24
• Mol File: 500025-30-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(3-THIEN-3-YL-1,2,4-OXADIAZOL-5-YL)PROPANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-THIEN-3-YL-1,2,4-OXADIAZOL-5-YL)PROPANOIC ACID(500025-30-9)
• EPA Substance Registry System: 3-(3-THIEN-3-YL-1,2,4-OXADIAZOL-5-YL)PROPANOIC ACID(500025-30-9)

Safety Data

• Hazardous Substances Data: 500025-30-9(Hazardous Substances Data)

Upstream product

• 58905-71-8 N'-hydroxythiophene-3-carboximidamide 
• 1641-09-4 3-thiophenecarbonitrile 

Relevant articles and documents

Room-temperature synthesis of pharmaceutically important carboxylic acids bearing the 1,2,4-oxadiazole moiety

An efficient and mild one-pot protocol has been developed for the synthesis of 1,2,4-oxadiazoles via the reaction of amidoximes with dicarboxylic acid anhydrides in a NaOH/DMSO medium. The method allows the synthesis of diversely substituted carboxylic acids bearing the 1,2,4-oxadiazole motif, – a popular building block for pharmaceutical research, in moderate to excellent yields. The reaction scope includes aromatic and heteroaromatic amidoximes as well as five-, six- and seven-membered anhydrides. The advantages of this procedure are proven gram-scalability and the use of inexpensive starting materials, which from a process chemistry point of view are essential for future industrial applications.