500136-13-0Relevant academic research and scientific papers
Investigation of the regioselectivity of the Hurde-Mori reaction for the formation of bicyclic1,2,3-thiadiazoles
Turner, Martin,Linder, Thomas,Schnürch, Michael,Mihovilovic, Marko D.,Stanetty, Peter
experimental part, p. 5472 - 5478 (2010/08/13)
A series of new pyrrolo[d][1,2,3]thiadiazole carboxylates and 5,6-dihydro-4H-cyclopenta[d][1,2,3]thia-diazoles has been synthesized via the HurdeMori reaction.The regioselectivity of the cyclization has been studied and trends were established to predict the cyclization direction to afford bicyclic 1,2,3-thiadiazoles.Effects promoting and disfavoring the reaction have also been investigated to guide the synthesis of scaffolds of this type.
