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500221-74-9

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500221-74-9 Usage

Uses

(2-Fluoro-benzyl)-pyridin-3-ylmethyl-amine can be prepared to use as HIV aspartyl protease inhibitors.

Check Digit Verification of cas no

The CAS Registry Mumber 500221-74-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,0,2,2 and 1 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 500221-74:
(8*5)+(7*0)+(6*0)+(5*2)+(4*2)+(3*1)+(2*7)+(1*4)=79
79 % 10 = 9
So 500221-74-9 is a valid CAS Registry Number.

500221-74-9Downstream Products

500221-74-9Relevant articles and documents

Optimized chemical probes for REV-ERBα

Trump, Ryan P.,Bresciani, Stefano,Cooper, Anthony W. J.,Tellam, James P.,Wojno, Justyna,Blaikley, John,Orband-Miller, Lisa A.,Kashatus, Jennifer A.,Boudjelal, Mohamed,Dawson, Helen C.,Loudon, Andrew,Ray, David,Grant, Daniel,Farrow, Stuart N.,Willson, Timothy M.,Tomkinson, Nicholas C. O.

, p. 4729 - 4737 (2013/07/19)

REV-ERBα has emerged as an important target for regulation of circadian rhythm and its associated physiology. Herein, we report on the optimization of a series of REV-ERBα agonists based on GSK4112 (1) for potency, selectivity, and bioavailability.(1) Potent REV-ERBα agonists 4, 10, 16, and 23 are detailed for their ability to suppress BMAL and IL-6 expression from human cells while also demonstrating excellent selectivity over LXRα. Amine 4 demonstrated in vivo bioavailability after either iv or oral dosing.

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