500221-77-2

Upstream product

• 748186-97-2 N-{4-[(3-methyl-butyl)-(2-oxo-azepan-3-yl)-sulfamoyl]-phenyl}-acetamide 
• 748186-99-4 methyl (2S)-6-amino-2-((4-aminophenylsulfonyl)(3-methylbutyl)amino)hexanoate 
• 748186-96-1 (S)-3-(3-Methyl-butylamino)-azepan-2-one 
• 21568-87-6 2-aminocaprolactam 
• 590-86-3 isovaleraldehyde 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 748187-00-0 4-amino-N-(5-amino-1-hydroxymethyl-pentyl)-N-(3-methyl-butyl)-benzenesulfonamide 
• 748186-98-3 (S)-6-Amino-2-[(4-amino-benzenesulfonyl)-(3-methyl-butyl)-amino]-hexanoic acid 

Relevant academic research and scientific papers

Lysine sulfonamides as novel HIV-protease inhibitors: Nε-disubstituted ureas

A series of lysine sulfonamide analogues bearing a Nε-benzylic ureas was synthesized using both solution-phase and solid-phase approaches. A novel synthetic route of Nα-(alkyl)-Nα-(sulfonamides)lysinol using α-amino-caprolactam was developed. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type HIV virus.