500283-06-7Relevant academic research and scientific papers
Immobilised Candida antarctica B as efficient catalyst for the synthesis of local anaesthetic intermediates
Giunta, Daniela,Masia, Maria Paola,Marchetti, Mauro,Morrone, Raffaele,Solinas, Maurizio
supporting information, p. 5122 - 5125 (2013/08/28)
We hereby present the development of new reaction conditions for the CALB catalysed esterification of substituted benzoic acids. Using cyclohexane as the reaction media a number of heptyl benzoates have been easily isolated in good to excellent yields (up to 100% at 80 C, 20-24 h). Moreover, the catalytic system has been successfully applied to the synthesis of local anaesthetics intermediates also showing good productivity in recycling experiments.
