5003-48-5 Usage
Originator
Benortan,Winthrop,Switz.
Uses
Benorilate is a codrug of Acetylsalicylic Acid (A187780) and Acetaminophen (A161220) and is used as an anti-inflammatory and antipyretic medication.
Manufacturing Process
Example 1: 65 grams of N-acetyl-p-aminophenol were slurried with 400 ml of
water and cooled to 10°C. 125 ml of 20% sodium hydroxide were slowly
added to the mixture with stirring, the temperature being maintained between
10°and 15°C. To the solution obtained, 75 grams of acetyl salicoyl chloride
were added with vigorous stirring over a period of 1/2 hr, the solution being
maintained at a temperature of about 10°C. Towards the end of the reaction
the pH was checked and adjusted to greater than 10 by the addition of a
small amount of 20% sodium hydroxide. After all the acid chloride had been
added, vigorous stirring was continued for half an hour during which time the
crude product separated out. This product was filtered off, washed thoroughly
with water and recrystallized from ethanol.
Example 2: 65 grams of sodium N-acetyl-p-aminophenol were slurried with
500 grams of dry benzene and 80 grams of acetyl salicoyl chloride added. The
mixture was heated under reflux for four hours and filtered hot. The excess
benzene was removed under vacuum and the crude acetyl salicyclic acid ester
of N-acetyl-p-aminophenol crystallized from ethanol.
Brand name
Benoral (Sterling Winthrop);Benolat;Benorile;Benotamol;Bentum;Doline;Durium;Duvium;Faw 76;Quinexin;Sinalgin;Spierifex;Triadol;Vetedol;Win 11450;Winolate;Winorlate;Winorylate;Winrolate;Wiolate.
World Health Organization (WHO)
Benorilate is the acetylsalicylic ester of paracetamol. See WHO
comment for acetylsalicylic acid.
Check Digit Verification of cas no
The CAS Registry Mumber 5003-48-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,0,0 and 3 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5003-48:
(6*5)+(5*0)+(4*0)+(3*3)+(2*4)+(1*8)=55
55 % 10 = 5
So 5003-48-5 is a valid CAS Registry Number.
InChI:InChI=1/C17H15NO5/c1-11(19)18-13-7-9-14(10-8-13)23-17(21)15-5-3-4-6-16(15)22-12(2)20/h3-10H,1-2H3,(H,18,19)
5003-48-5Relevant articles and documents
Preparation method of benorilate
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Paragraph 0021-0037, (2020/05/05)
The invention relates to a preparation method of benorilate, which relates to the technical field of medicine synthesis. According to the invention, acetylsalicylic acid and acetaminophen are used asraw materials to directly synthesize behenolate under the condition of common catalysis of azodicarboxylic acid ester compounds and triphenylphosphine. The preparation method comprises the following steps: adding acetaminophen and a light-delay reaction catalyst I triphenylphosphine into a reaction bottle, adding an organic solvent, adding a light-delay reaction catalyst II, and uniformly mixing;and adding acetylsalicylic acid in batches within 20 minutes, stirring in an ice bath for 20 minutes, heating to normal temperature, magnetically stirring, and reacting for 8.5 hours to obtain the benorilate. According to the present invention, the acetylsalicylic acid and the p-acetamidophenol are catalyzed by using a light delay reaction catalysis system so as to be esterified, such that the steps are simple, the drugs only need to be sequentially added, the process route is short, and the synthesis cost is effectively reduced.
