500337-32-6Relevant academic research and scientific papers
Synthesis, anticholinesterase activity and molecular modeling study of novel carbamate-substituted thymol/carvacrol derivatives
Kurt, Belma Zengin,Gazioglu, Isil,Dag, Aydan,Salmas, Ramin Ekhteiari,Kay?k, Gülru,Durdagi, Serdar,Sonmez, Fatih
, p. 1352 - 1363 (2017)
New thymol and carvacrol derivatives with the carbamate moiety were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 5-isopropyl-2-methylphenyl(3-fluorophenyl)carbamate (29) was foun
Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds
Ortar, Giorgio,Morera, Ludovica,Schiano Moriello, Aniello,Morera, Enrico,Nalli, Marianna,Di Marzo, Vincenzo,De Petrocellis, Luciano
supporting information; experimental part, p. 3535 - 3539 (2012/07/03)
A series of thirty-three thymol, p-cymene-3-carboxylic acid, and 3-amino-p-cymene derivatives was synthesized and tested on TRPA1, TRPM8, and TRPV3 channels. Most of them acted as strong modulators of TRPA1, TRPM8, and TRPV3 channels with EC50 and/or IC50 values distinctly lower than those of thymol and related monoterpenoids. Some of the compounds examined, that is, 3c, 4e, f, 6b, and 8b exhibited an appreciable subtype-selectivity.
