500358-80-5Relevant academic research and scientific papers
Iron-Mediated One-Pot Synthesis of 3,5-Diarylpyridines from β-Nitrostyrenes
Sathish, Manda,Chetna, Jadala,Hari Krishna, Namballa,Shankaraiah, Nagula,Alarifi, Abdullah,Kamal, Ahmed
, p. 2159 - 2165 (2016)
An operationally simple and mild one-pot protocol for the synthesis of a variety of 3,5-diarylpyridines from β-nitrostyrenes was achieved by using elemental iron. This reaction proceeds via reduction of the nitro group, resulting in in situ imine formation followed by trimolecular condensation with concomitant debenzylative aromatization. By employing this method, a series of symmetrical and unsymmetrical 3,5-diarylpyridines were synthesized with good to excellent yields. In addition, this method was also utilized for the synthesis of Sch-21418, an anti-inflammatory agent on gram scale.
Anti-tumor application of pyridine-containing compound
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Paragraph 0007; 0021-0022, (2021/11/27)
The invention relates to an anti-tumor application of a pyridine-containing compound. The pyridine-containing compound is a compound JKW-14, and has an anti-proliferation effect on a plurality of tumor cells.
Cu-Catalyzed concise synthesis of pyridines and 2-(1 H)-pyridones from acetaldehydes and simple nitrogen donors
Li, Ziyuan,Huang, Xiaoqiang,Chen, Feng,Zhang, Chun,Wang, Xiaoyang,Jiao, Ning
supporting information, p. 584 - 587 (2015/03/04)
A highly selective copper-catalyzed concise synthesis of 3,5-diarylpyridine and 2-(1H)-pyridone has been achieved through cascade Chichibabin-type cyclization, C(sp3)-C(sp3) cleavage, and aerobic oxidation. Azide, ceric ammonium nitrate (CAN), and 2-aminopyridine are disclosed as efficient nitrogen donors in this Cu-catalysis using O2 as the oxidant. Water and molecular oxygen were employed as the oxygen source in the case of oxygenation.
Metal-free synthesis of substituted pyridines from aldehydes and NH4OAc under air
Yan, Rulong,Zhou, Xiaoqiang,Li, Ming,Li, Xiaoni,Kang, Xing,Liu, Xingxing,Huo, Xing,Huang, Guosheng
, p. 50369 - 50372 (2014/12/10)
A metal-free and efficient method for the synthesis of substituted pyridines with aldehydes and NH4OAc under mild conditions using air as the oxidant was developed. This oxidative cyclization process involves direct C-H bond functionalization, C-C/C-N bond formation and C-C bond cleavage.
