500370-33-2Relevant academic research and scientific papers
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: Azoles: Effective metal chelators
Le, Giang,Vandegraaff, Nick,Rhodes, David I.,Jones, Eric D.,Coates, Jonathan A.V.,Thienthong, Neeranat,Winfield, Lisa J.,Lu, Long,Li, Xinming,Yu, Changjiang,Feng, Xiao,Deadman, John J.
scheme or table, p. 5909 - 5912 (2010/11/18)
Synthesis of a diverse set of azoles and their utilizations as an amide isostere in the design of HIV integrase inhibitors is described. The Letter identified thiazole, oxazole, and imidazole as the most promising heterocycles. Initial SAR studies indicat
ANTIVIRAL AGENT
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Page 183, (2010/02/06)
The present invention provides an integrase inhibitor. The inventors have have found the following compound of formula (I) possessing an integrase inhibitory activity. (wherein, R C and R D taken together with the neighboring carbon atoms form a ring which may be a condensed ring, Y is hydroxy, mercapto or amino; Z is O, S or NH ; R A is a group shown by (wherein, C ring is N-containing aromatic heterocycle) or the like)
