5005-40-3

Usage

Uses

Used in Organic Synthesis:
Phenyl(pyridin-3-yl)acetonitrile is utilized as a building block in organic synthesis, serving as a key component in the creation of various complex molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, phenyl(pyridin-3-yl)acetonitrile is employed as a starting material for the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Development:
phenyl(pyridin-3-yl)acetonitrile also has potential applications in the agrochemical sector, where it is used in the synthesis of new agrochemicals, potentially leading to more effective crop protection products.
Used in Fine Chemicals Production:
Phenyl(pyridin-3-yl)acetonitrile is an intermediate in the production of various fine chemicals, playing a crucial role in the synthesis of specialty chemicals that have diverse applications across industries.
Used in Dye Manufacturing:
Additionally, phenyl(pyridin-3-yl)acetonitrile is involved in the manufacturing of dyes, where it contributes to the development of new colorants for various applications, including textiles, plastics, and printing inks.

Upstream product

• 626-60-8 3-Chloropyridine 
• 140-29-4 phenylacetonitrile 
• 6270-47-9 1-phenyl-1-(pyrid-3-yl)methanol 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 372-47-4 3-Fluoropyridine 
• 626-55-1 3-Bromopyridine 

Downstream Products

• 21883-33-0 phenyl-pyridin-3-yl-acetic acid 
• 308806-04-4 2-phenyl-2-(pyrid-3-yl)ethylamine methyl carbamate 
• 5424-19-1 3-Benzoylpyridine 

Relevant academic research and scientific papers

INHIBITORS OF HISTONE DEACETYLASE

This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.

Synthesis of substituted pyridines by the reactions of halopyridines with sulfur, oxygen and carbon nucleophiles under focused microwave irradiation

The nucleophilic substitution reactions of halopyridines with sulfur, oxygen and carbon nucleophiles under microwave irradiation was complete within several minutes with yields up to 99%. The method using microwave irradiation is superior to those conducted under conventional heating processes.

Anti-viral method

PCT No. PCT/US97/07431 Sec. 371 Date Jan. 6, 1999 Sec. 102(e) Date Jan. 6, 1999 PCT Filed May 2, 1997 PCT Pub. No. WO97/41846 PCT Pub. Date Nov. 13, 1997The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.

Urea, thiourea and guanidine compounds and their use as anti-viral agents

The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.

REACTIONS OF β-BROMO-N-HETEROAROMATICS WITH PHENYLACETONITRILE

The reaction of 3-bromopyridine with phenylacetonitrile in the presence of NaH in THF gave a simple substitution product, α-phenyl-3-pyridineacetonitrile, whereas the reaction of 5-bromopyrimidine with phenylacetonitrile under similar conditions gave a ring-transformation product, 2-amino-5-bromo-3-phenylpyridine. 3-Bromoquinoline and 4-bromoisoquinoline underwent the former type reaction, while 3-bromo- and 3-chloroisoquinolines were converted into 2-amino-3-phenyl-1-naphthalenecarbonitrile according to the latter type reaction.

A New Synthesis of Aryl Hetaryl Ketones via SRN1 Reaction of Halogenated Heterocycles withPotassiophenylacetonitrile Followed by Phase-Transfer Catalyzed Decyanation

Reaction of halogenated pyridines, quinolines, pyrimidines, and pyrazines with potassiophenylacetonitrile (5) in liquid ammonia under near-uv irradiation affords secondary nitriles, which then undergo oxidative decyanation under phase-transfer catalytic conditions to afford aryl hetaryl ketones in excellent yields.