500709-26-2Relevant academic research and scientific papers
Enantioselective carbocycle formation through intramolecular Pd-catalyzed allyl-aryl cross-coupling
Schuster, Christopher H.,Coombs, John R.,Kasun, Zachary A.,Morken, James P.
supporting information, p. 4420 - 4423 (2015/01/09)
Aryl electrophiles containing tethered allylboronate units undergo efficient intramolecular coupling in the presence of a chiral palladium catalyst to give enantioenriched carbocyclic products. The reaction is found to be quite general, affording 5, 6, an
The versatile role of norbornene in C-H functionalization processes: concise synthesis of tetracyclic fused pyrroles via a threefold domino reaction
Gericke, Kersten M.,Chai, David I.,Lautens, Mark
, p. 6002 - 6014 (2008/12/20)
The synthesis of novel tetracyclic fused pyrroles from 1-(2-iodophenyl)-1H-pyrrole and various bromoalkyl-aryl alkynes via a palladium(0)-catalyzed and norbornene-mediated threefold domino reaction is reported. PdCl2 and tri-2-furylphosphine (TFP) in the presence of norbornene and Cs2CO3 in CH3CN at 90 °C gave a variety of tetracyclic fused pyrroles in usually high yields. In the described reaction sequence two of the three carbon-carbon bonds are formed by functionalization of an unactivated aryl C-H bond.
