500757-99-3Relevant articles and documents
Synthesis of B,B-dinor-B-secosteroids as potential cardenolide analogues
Sevillano, Luis G.,Caballero, Esther,Tomé, Fernando,Medarde, Manuel,San Feliciano, Arturo
, p. 10103 - 10112 (2002)
A novel chemical construction of B,B-dinor-B-secosteroids as simplified cardenolide analogs, starting from the Hajos-Parrish diketone was developed. The synthesis of the equivalent of the steroid A ring was carried out through a Diels-Alder reaction between an appropriate hydroindenyl acrylate derivative and Danishefsky's diene.