500764-03-4Relevant academic research and scientific papers
Loxoprofen sodium and preparation method of intermediate of loxoprofen sodium
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Paragraph 0046; 0047; 0048; 0049, (2017/09/29)
The invention relates to the technical field of organic synthesis and in particular relates to loxoprofen sodium and a preparation method of an intermediate of the loxoprofen sodium. The invention provides a compound with a structure shown as a formula A: the formula A is shown in the description, wherein R and R are independently selected from methyl or ethyl or can be subjected to cyclic synthesis to form a formula shown in the description respectively, wherein n is 1 or 2; Y is X or a formula shown in the description, wherein X is Cl or Br and R is methyl or ethyl.
Synthesis of the precursor of anti-inflammatory agents by cross-coupling using electrogenerated highly reactive zinc
Jalil, Aishah A.,Kurono, Nobuhito,Tokuda, Masao
, p. 2681 - 2686 (2007/10/03)
Highly reactive zinc metal was readily prepared by electrolysis of a DMF solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. This reactive zinc was used for efficient transformation of ethyl 2-bromoacrylate into the corresponding organozinc compound, which was reacted with various aryl iodides in the presence of palladium catalyst to give the corresponding cross-coupling products, ethyl 2-arylpropenoates, in high yields. These cross-coupling reactions were successfully applied to a synthesis of the precursors of non-steroidal anti-inflammatory agents such as ibuprofen, naproxen, ketoprofen, loxoprofen, indoprofen, suprofen, cicloprofen, and flurbiprofen.
