500767-06-6Relevant articles and documents
Design and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium falciparum-infected cultured human erythrocytes
N?teberg, Daniel,Hamelink, Elizabeth,Hultén, Johan,Wahlgren, Mats,Vrang, Lotta,Samuelsson, Bertil,Hallberg, Anders
, p. 734 - 746 (2007/10/03)
A series of protease inhibitors targeted at the malarial enzymes plasmepsin I and II, and encompassing a basic hydroxyethylamine transition state isostere scaffold, was prepared. The substituents in the P1′ position were varied and the biological activiti