500773-48-8

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 500773-43-3 1-((2R,4S)-4-Allyloxy-5,5-bis-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 376394-39-7 3'-O-(prop-2-enyl)-5'-O-tert-butyldimethylsilylthymidine 
• 211191-57-0 3’-allyl ether thymidine 
• 50-89-5 thymidine 
• 40733-28-6 5'-tert-butyldimethylsilyloxy-2'-deoxythymidine 

Downstream Products

• 500773-47-7 1-[7a-(tert-butyl-diphenyl-silanyloxymethyl)-3,3a,5,7a-tetrahydro-2H-furo[3,2-b]pyran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 500773-45-5 3-allyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-carbaldehyde 
• 500773-46-6 1-[4-allyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 500773-44-4 1-[4-allyloxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Synthesis of 4′-C, 3′-O bicyclic thymidine analogues using ring closure metathesis

We have developed a route to the synthesis of new six-membered ring bicyclic nucleoside analogues. The synthesis of 4′-C, 3′-O bicyclic thymidine analogues is presented as first examples of this new family. Six-membered ring construction was efficiently achieved by the application of ring closure olefin metathesis on a diene intermediate using Grubbs' catalyst.