500794-91-2Relevant academic research and scientific papers
Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor
Koehler, Konrad,Gordon, Sandra,Brandt, Peter,Carlsson, Bo,B?cksbro-Saeidi, Anna,Apelqvist, Theresa,Agback, Peter,Grover, Gary J.,Nelson, William,Grynfarb, Marlena,F?rneg?rdh, Mathias,Rehnmark, Stefan,Malm, Johan
, p. 6635 - 6637 (2007/10/03)
A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.
