500795-35-7

Upstream product

• 2746-25-0 p-Methoxybenzyl bromide 
• 500795-17-5 (1'S,3S,4S,6E) 2-ethoxy-4-(1'-methoxymethoxy-hexyl)-6-methyl-7-(trimethylsilanyl)-hepta-1,6-dien-3-ol 
• 500795-41-5 (2R,3S)-3-Methoxymethoxy-2-((E)-2-methyl-3-trimethylsilanyl-allyl)-octanoic acid methoxy-methyl-amide 
• 500795-43-7 (4R,5S)-2-Ethoxy-5-methoxymethoxy-4-((E)-2-methyl-3-trimethylsilanyl-allyl)-dec-1-en-3-one 
• 500795-33-5 (4R) 4-benzyl-3-[2-(1'S,2R,4E)-(1'-methoxymethoxy-hexyl)-4-methyl-5-(trimethylsilanyl)-pent-4-enoyl]-oxazolidin-2-one 
• 500795-16-4 (1'S,2S,4E) 2-(1'-methoxymethoxy-hexyl)-4-methyl-5-(trimethylsilanyl)-pent-4-en-1-ol 
• 327165-41-3 (4R)-4-benzyl-3-[(2R,3S)-2-(2-methyl-3-trimethylsilyl-E-2-propen-1-yl)-3-hydroxyoctanoyl]-oxazolidin-2-one 

Downstream Products

• 500795-18-6 (1'S,3S,4R,6E) 3-p-methoxybenzyloxy-4-(1'-methoxymethoxy-hexyl)-6-methyl-7-(trimethylsilanyl)-hept-6-en-2-one 
• 500795-37-9 (1'S,4S,5S,6R,8E) 5-p-methoxybenzyloxy-6-(1'-methoxymethoxy-hexyl)-4,8-dimethyl-9-(trimethylsilanyl)-non-8-en-2-yn-4-ol 

Relevant academic research and scientific papers

Total synthesis of formamicin

The enantioselective total synthesis of the cytotoxic plecomacrolide natural product formamicin (1) is described. Key aspects of this synthesis include the efficient transacetalation reactions of MOM ethers 28 and 38 to form the seven-membered formyl acet

Total synthesis of the formamicin aglycon, formamicinone.

[structure: see text] The total synthesis of formamicinone (2), the aglycone of formamicin (1), has been accomplished via the late-stage Suzuki cross-coupling of fragments 5 and 6, the macrolactonization of seco ester 14, and the Mukaiyama aldol reaction