5008-52-6

Usage

Uses

Used in Pharmaceutical Industry:
Napelline is used as a potential active ingredient for pain-relief medications due to its notable anti-inflammatory and analgesic properties. Its ability to alleviate pain and reduce inflammation makes it a candidate for the development of new therapeutic agents.
Used in Research and Development:
In the field of medicinal chemistry, NAPELLINE is used as a subject of study for understanding its mechanism of action and potential applications in treating pain and inflammation. This research can lead to the discovery of new drug formulations or the enhancement of existing ones.

InChI:InChI=1/C22H33NO3/c1-4-23-10-20(3)6-5-17(25)22-15(20)7-13(18(22)23)21-9-12(11(2)19(21)26)14(24)8-16(21)22/h12-19,24-26H,2,4-10H2,1,3H3/t12?,13?,14-,15+,16+,17-,18?,19+,20-,21?,22?/m0/s1

Upstream product

• 509-24-0 songorine 
• 5008-49-1 12-epi-lucidusculine 

Downstream Products

• 137031-43-7 liangshanine 
• 137051-51-5 C₄₂H₅₅NO₅Si 
• 137038-71-2 C₃₇H₄₃NO₅ 
• 137038-70-1 C₃₆H₄₁NO₅ 

Relevant academic research and scientific papers

Antiarrhythmic agents based on diterpenoid alkaloids

Diterpenoid alkaloids comprise a large group of natural compounds produced by the plants of the genera Aconitum and Delphinium. Some of these compounds were found to manifest valuable pharmacological properties, including the unique antiarrhythmic activity. Allapinine (derived from the alkaloid lappaconitine) was approved as a drug. The investigation of the structure-activity relationship revealed structural elements responsible for the arrhythmogenic and antiarrhythmic properties.

Five new napelline-type diterpene alkaloids from Aconitum liangshanium

The structures of five new C20-diterpene alkaloids having the napelline skeleton, i.e., 12-epi-lucidusculine (2), 12-epi-19-dehydronapelline (8), 12-epi-19-dehydrolucidusculine (9), liangshanine (3), and liangshanone (11), found from the roots of Aconitum liangshanium, were determined by spectroscopic analysis and chemical reactions.

ALKALOIDS OF THE EPIGEAL PART OF Aconitum karakolicum. THE STRUCTURE OF 12-EPINAPELLINE

A new alkaloid has been isolated from the eipgeal part of the Aconitum karakolicum Rapaics. and has been called 12-epinapelline.The structure of the new alkaloid has been shown by the preparation of a diacetate and an iso derivative and also by the direct passage from songorine to 12-epinapelline and a study of their spectral characteristics.