Cas 500889-14-5,6-benzyl-N-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

500889-14-5

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Basic information

Product Name: 6-benzyl-N-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine
Synonyms: 6-benzyl-N-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine
CAS NO:500889-14-5
Molecular Formula:
Molecular Weight: 316.406
EINECS: N/A
Product Categories: N/A
Mol File: 500889-14-5.mol
Article Data: 2

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 6-benzyl-N-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine(CAS DataBase Reference)
NIST Chemistry Reference: 6-benzyl-N-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine(500889-14-5)
EPA Substance Registry System: 6-benzyl-N-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine(500889-14-5)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 500889-14-5(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 500889-14-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,0,8,8 and 9 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 500889-14:
(8*5)+(7*0)+(6*0)+(5*8)+(4*8)+(3*9)+(2*1)+(1*4)=145
145 % 10 = 5
So 500889-14-5 is a valid CAS Registry Number.

500889-14-5Upstream product

500889-14-5Downstream Products

914612-26-3 5,6,7,8-tetrahydro-N-phenylpyrido[4,3-d]pyrimidin-4-amine

500889-14-5Relevant articles and documents

Structure-property studies of an imidazoquinoline chemotype with antitrypanosomal activity

Bosch-Navarrete, Cristina,Buskes, Melissa J.,Dalton, Raeann M.,Delano, Travis J.,Devine, William G.,Diaz-Gonzalez, Rosario,Ferrins, Lori,Fisher, John K.,Fritsche, Melanie G.,Gamarro, Francisco,Hilborne, Vivian,Klug, Dana M.,Manzano-Chinchon, Pilar,Martinez-Martinez, Maria Santos,Mavrogiannaki, Eftychia M.,Navarro, Miguel,Pollastri, Michael P.,Schneider, Katherine M.,Simpson, Quillon J.,Tear, Westley F.,Ceballos-Pérez, Gloria,García-Hernández, Raquel,González-Pacanowska, Dolores,Pérez-Moreno, Guiomar,Ruiz-Pérez, Luis Miguel

supporting information, p. 950 - 959 (2020/09/15)

Human African trypanosomiasis is a neglected tropical disease (NTD) that is fatal if left untreated. Although approximately 13 million people live in moderate- to high-risk areas for infection, current treatments are plagued by problems with safety, efficacy, and emerging resistance. In an effort to fill the drug development pipeline for HAT, we have expanded previous work exploring the chemotype represented by the compound NEU-1090, with a particular focus on improvement of absorption, distribution, metabolism and elimination (ADME) properties. These efforts resulted in several compounds with substantially improved aqueous solubility, although these modifications typically resulted in a loss of trypanosomal activity. We herein report the results of our investigation into the antiparasitic activity, toxicity, and ADME properties of this class of compounds in the interest of informing the NTD drug discovery community and avoiding duplication of effort.

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