500893-17-4Relevant academic research and scientific papers
Rh(iii)-Catalyzed: Ortho -C-(sp2)-H amidation of ketones and aldehydes under synergistic ligand-accelerated catalysis
Hande, Akshay Ekanath,Ramesh, Vinay Bapu,Prabhu, Kandikere Ramaiah
supporting information, p. 12113 - 12116 (2018/11/21)
Rh(iii)-Catalyzed ortho-C-H amidation of ketones and aldehydes under cooperative metal organocatalysis has been utilized for synthesizing various ortho-amidocarbonyl analogs, and the reaction for the aldehyde proceeds at ambient temperature. The aniline derivative 3,5-bis(trifluoromethyl)aniline promotes the amidation reaction via a transient imine directing group. The efficient amidation agent is dioxazolone. The synthetic utility has been demonstrated in the synthesis of quindolinone alkaloids.
