500997-69-3

Usage

Uses

Used in Pharmaceutical Industry:
(R)-SIPHOS-PE is used as a catalyst in the preparation of tricyclic alkaloid (+)-aphanorphine via asymmetric carboamination and Friedel-Crafts reaction. Its high enantioselectivity and reactivity enable the efficient synthesis of biologically active compounds with potential pharmaceutical applications.
Used in Chemical Synthesis:
(R)-SIPHOS-PE is used as a ligand in the synthesis of chiral ketones via hydroacylation of olefins using salicylaldehyde derivatives. Its unique structure and properties allow for the enantioselective formation of chiral ketones, which are important building blocks in the synthesis of various pharmaceuticals, agrochemicals, and natural products.
Used in Organic Chemistry Research:
(R)-SIPHOS-PE is used as a ligand in the enantioselective synthesis of substituted pyrrolidine derivatives via Pd-catalyzed alkene aminoarylation reactions. Its ability to promote enantioselective transformations makes it a valuable tool for the development of new synthetic methods and the preparation of enantioenriched compounds for biological evaluation and application.

Reaction

Chiral ligands for copper-catalyzed asymmetric allylic alkylation with dialkylzincs. Chiral ligands for copper-catalyzed asymmetric conjugate addition of diethylzinc to enones. Chiral ligands for palladium-catalyzed asymmetric hydrosilylation of styrenes Chiral ligands for copper-catalyzed asymmetric ring-opening of oxabicyclic alkenes with Grignard reagents. Chiral ligands for nickel-catalyzed asymmetric hydrovinylation of α-alkyl vinylarenes. Chiral ligands for iridium-catalyzed asymmetric hydrogenation of cyclic enamines. Chiral ligands for iridium-catalyzed asymmetric hydrogenation of cyclic imines. Chiral ligands for gold-catalyzed asymmetric [2 + 2] cycloaddition reaction. Chiral ligands for rhodium-catalyzed asymmetric hydroacylation of salicylaldehydes to homoallylic sulfides. Chiral ligands for palladium-catalyzed asymmetric carboamination reactions.