501013-47-4Relevant academic research and scientific papers
Synthesis and biological evaluation of 5R- and 5S-methyl substituted D- and L-configuration 1,3-dioxolane nucleoside analogs
Bera, Sanjib,Malik, Leila,Bhat, Balkrishen,Carroll, Steven S.,Hrin, Renee,MacCoss, Malcolm,McMasters, Daniel R.,Miller, Michael D.,Moyer, Greg,Olsen, David B.,Schleif, William A.,Tomassini, Joanne E.,Eldrup, Anne B.
, p. 6237 - 6247 (2007/10/03)
1,3-Dioxolane and 1,3-oxathiolane nucleoside analogs play an important role in anti-viral and anti-neoplastic chemotherapy. We report here the synthesis of 2-hydroxymethyl-5-methyl-1,3-dioxolanylpurine nucleosides from 4-acetoxy-2-(benzyloxymethyl)-5-meth
Synthesis and evaluation of optically pure dioxolanes as inhibitors of hepatitis C virus RNA replication
Bera, Sanjib,Malik, Leila,Bhat, Balkrishen,Carroll, Steven S.,MacCoss, Malcolm,Olsen, David B.,Tomassini, Joanne E.,Eldrup, Anne B.
, p. 4455 - 4458 (2007/10/03)
A series of optically pure 1,3-dioxolane nucleoside mimics was synthesized by a synthetic route that allowed incorporation of a 5R-methyl substituent from commercially available starting materials. The pyrrolo[2,3-d]pyrimidine heterocycle was chosen as a
