501031-47-6Relevant articles and documents
Synthesis and evaluation of novel α-heteroaryl-phenylpropanoic acid derivatives as PPARα/γ dual agonists
Casimiro-Garcia, Agustin,Bigge, Christopher F.,Davis, Jo Ann,Padalino, Teresa,Pulaski, James,Ohren, Jeffrey F.,McConnell, Patrick,Kane, Christopher D.,Royer, Lori J.,Stevens, Kimberly A.,Auerbach, Bruce,Collard, Wendy,McGregor, Christine,Song, Kun
experimental part, p. 7113 - 7125 (2010/03/30)
The synthesis of a new series of phenylpropanoic acid derivatives incorporating an heteroaryl group at the α-position and their evaluation for binding and activation of PPARα and PPARγ are presented in this report. Among the new compounds, (S)-3-{4-[3-(5-