501037-55-4

Upstream product

• 54153-19-4 2-cyano-N-m-tolylacetamide 

Downstream Products

• 1453263-54-1 6-amino-4-isobutyl-2-thioxo-N³,N⁵-di-m-tolyl-1,2,3,4-tetrahydropyridine-3,5-dicarboxamide 
• 1453263-64-3 2-amino-6-benzylsulfanyl-4-isobutyl-N³,N⁵-di-m-tolyl-3,4-dihydropyridine-3,5-dicarboxamide 
• 1338443-34-7 6-amino-5-cyano-4-methylsulfanyl-N₃-phenyl-2-thioxo-1,2-dihydropyridine-3-carboxamide 
• 1146770-66-2 N⁽³⁾-(3-tolyl)-N⁽⁵⁾-phenyl-6-amino-4-(4-chlorophenyl)-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxamide 

Relevant academic research and scientific papers

E-Z-izomerization of 2-methylenethiazolidin-4-ones

The equilibrium concentrations of E- and Z-isomers of thiazolidin-4-ones containing exocyclic double bonds in positions 2 and 5 of the cycle were determined in DMSO-d6. The influence of the nature of the substituents on the equilibrium position was found. Electron-releasing substituents stabilize the E,Z-configuration and electron-withdrawing substituents stabilize the Z,Z-configuration. The association constants of E- and Z-2-ethoxycarbonylmethylenethiazolidin-4-ones with the sodium cation were determined by 1H NMR spectroscopy.