501084-23-7

Upstream product

• 97747-37-0 (1S,3S,4S)-3-hydroxymethyl-4-methyl-1-phenyl-1,3-dioxane 
• 1125-88-8 benzaldehyde dimethyl acetal 

Downstream Products

• 1032989-81-3 C₃₂H₃₅NO₈ 
• 1032989-85-7 C₃₂H₄₈O₆Si 
• 1032989-98-2 C₃₇H₇₂O₆Si₃ 
• 1032989-86-8 C₃₁H₅₈O₆Si₂ 
• 1032989-99-3 C₃₈H₆₁NO₅S₂Si₂ 
• 1032989-77-7 2-((2R,3S,4R,5S,6S)-6-methoxy-5-(4-methoxybenzyloxy)-2-methyl-3,4-bis(triethylsilyloxy)non-8-enylsulfonyl)benzo[d]thiazole 
• 1032989-83-5 C₃₀H₄₅NO₇Si 
• 1032989-82-4 C₃₁H₄₄O₆Si 
• 1032989-84-6 C₃₁H₄₆O₆Si 
• 1032989-97-1 C₁₉H₃₀O₆ 
• 97747-37-0 (1S,3S,4S)-3-hydroxymethyl-4-methyl-1-phenyl-1,3-dioxane 
• 501084-26-0 (2S,3S)-3-hydroxy-2-methyl-3-[(2R,4R,5R)-5-methyl-2-phenyl-1,3-dioxan-4-yl]-1-[(2S,4S,5S)-5-methyl-2-phenyl-1,3-dioxan-4-yl]propan-1-one 
• 501084-27-1 (2S,3R)-3-hydroxy-2-methyl-3-[(2R,4R,5R)-5-methyl-2-phenyl-1,3-dioxan-4-yl]-1-[(2S,4S,5S)-5-methyl-2-phenyl-1,3-dioxan-4-yl]propan-1-one 
• 501084-25-9 1-[(2S,4S,5S)-5-methyl-2-phenyl-1,3-dioxan-4-yl]-1-propanone 

Relevant academic research and scientific papers

Diarylprolinol-Mediated Asymmetric Direct Cross-Aldol Reaction of α,β-Unsaturated Aldehyde as an Electrophilic Aldehyde

The diarylprolinol-mediated asymmetric direct cross-aldol reaction of α,β-unsaturated aldehyde as an electrophilic aldehyde was developed. The reaction becomes accelerated by an acid when a carbonyl group is introduced at the γ-position of the α,β-unsatur

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments

Due to a combination of their promising anticancer properties, limited supply from the marine sponge source and their unprecedented molecular architecture, spirastrellolides represent attractive and challenging synthetic targets. A modular strategy for the synthesis of spirastrellolide A methyl ester, which allowed for the initial stereochemical uncertainties in the assigned structure was adopted, based on the envisaged sequential coupling of a series of suitably functionalised fragments; in this first paper, full details of the synthesis of these fragments are described. The pivotal C26-C40 DEF bis-spiroacetal was assembled by a double Sharpless asymmetric dihydroxylation/acetalisation cascade process on a linear diene intermediate, configuring the C31 and C35 acetal centres under suitably mild acidic conditions. A C1-C16 alkyne fragment was constructed by application of an oxy-Michael reaction to introduce the A-ring tetrahydropyran, a Sakurai allylation to install the C9 hydroxyl, and a 1,4-syn boron aldol/directed reduction sequence to establish the C11 and C13 stereocentres. Two different coupling strategies were investigated to elaborate the C26-C40 DEF fragment, involving either a C17-C25 sulfone or a C17-C24 vinyl iodide, each of which was prepared using an Evans glycolate aldol reaction. The remaining C43-C47 vinyl stannane fragment required for introduction of the unsaturated side chain was prepared from (R)-malic acid.

Total synthesis of spirastrellolide A methyl ester - Part 1: Synthesis of an advanced C17-C40 bis-spiroacetal subunit

Out of the blue: The marine macrolide spirastrellolide A is a potent and selective inhibitor of protein phosphatase 2A and a lead for anticancer therapies. A flexible and modular synthetic strategy has been developed with two routes for the construction o

Synthesis and conformational analysis of meso-ter(1,3-dioxan-4-yls)

A convergent synthesis of the meso-ter(1,3-dioxanyls) 8-11 has been achieved, starting from two enantiomeric building blocks in each case. The stereogenic centres in the central linkage region were set up by stereocontrolled aldol additions. Structure ass