501098-87-9

Basic information

• Product Name: 2-Propynal, 3-(2-chlorophenyl)-
• CAS NO: 501098-87-9
• Molecular Formula: C9H5ClO
• Molecular Weight: 164.591
• Mol File: 501098-87-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-Propynal, 3-(2-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propynal, 3-(2-chlorophenyl)-(501098-87-9)
• EPA Substance Registry System: 2-Propynal, 3-(2-chlorophenyl)-(501098-87-9)

Safety Data

• Hazardous Substances Data: 501098-87-9(Hazardous Substances Data)

Upstream product

• 873-31-4 2-chlorophenylacetylene 
• 68-12-2 N,N-dimethyl-formamide 
• 558-13-4 carbon tetrabromide 
• 89-98-5 2-chloro-benzaldehyde 
• 80151-26-4 3-(2-chlorophenyl)-prop-2-yn-1-ol 
• 401514-40-7 1-chloro-2-(2,2-dibromovinyl)benzene 
• 1095509-79-7 1-chloro-2-(3,3-diethoxy-prop-1-ynyl)-benzene 

Relevant articles and documents

Chiral β-Keto Propargylamine Synthesis via Enantioselective Mannich Reaction of Enamides with C-Alkynyl N-Boc N, O-Acetals

Propargylamines are an important class of compounds in organic synthesis and drug discovery, yet the synthesis of chiral β-keto propargylamines remains underdeveloped. Herein, we describe a streamlined and general enantioselective Mannich reaction of enamides with C-alkynyl N-Boc N,O-acetals, which serve as readily available C-alkynyl imine precursors, to access a broad range of chiral β-keto N-Boc-propargylamines bearing single stereogenic centers in high yields (up to 98%) and in high enantioselectivities (up to 95% ee).

NHC-catalyzed enantioselective C2-functionalization of 3-hydroxychromenonesviaα,β-unsaturated acyl azoliums

A novel synthetic method for enantioselective C2-functionalization of 3-hydroxychromenones promoted by N-heterocyclic carbenesviathe formation of α,β-unsaturated acyl azolium intermediates, which occurs with Coates-Claisen rearrangement is established. This synthetic strategy enabled the rapid assembly of enantiomerically enriched δ-hydroxychromenone-derived esters/amides under mild conditions with good to excellent yields and broad substrate scope.

Copper-Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes

A copper-catalyzed silylation of propargyl dichlorides was developed to access chloro-substituted allenylsilanes under mild reaction conditions. Moreover, enantioenriched chloro-substituted allenylsilanes can be synthesized in moderate to high yields and good enantioselectivities with this protocol.