501121-63-7Relevant academic research and scientific papers
Novel fluoropeptidomimetics: Synthesis, stability studies and protease inhibition
Annedi, Subhash C.,Majumder, Kanchana,Wei, Lianhu,Oyiliagu, Catherine E.,Samson, Sheeba,Kotra, Lakshmi P.
, p. 2943 - 2958 (2007/10/03)
Designer fluoropeptidomimetics as protease inhibitors are revealed. The key peptidomimetic region in the inhibitors contains a '-CHF-S-' moiety and is designed to mimic the tetrahedral oxyanion species during the hydrolysis of a peptide bond. Designed flu
Design and synthesis of novel fluoropeptidomimetics as potential mimics of the transition state during peptide hydrolysis
Annedi, Subhash C.,Li, Weiyong,Samson, Sheeba,Kotra, Lakshmi P.
, p. 1043 - 1049 (2007/10/03)
α-Fluoroamino acids were targeted in our ongoing efforts to design novel fluoropeptidomimetics (1) as potential protease inhibitors. α-Fluoroglycine derivative (2) and α-fluoro-β-aminoethanethiol derivatives (3-9) were synthesized for the first time en ro
