501121-90-0

Upstream product

• 501121-89-7 benzyl 8-oxa-4-azabicyclo[5.1.0]octane-4-carboxylate 
• 501121-88-6 benzyl 2,3,6,7-tetrahydro-1H-azepine-1-carboxylate0 

Downstream Products

• 1338718-26-5 tert-butyl 4-(5-(4,4-difluoro-5-(2,2,2-trifluoroacetamido)azepan-1-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate 
• 1338718-19-6 benzyl 4-azido-5-oxoazepane-1-carboxylate 

Relevant academic research and scientific papers

COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF

Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, psychiatric disorders, neuromuscular disorders, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds provided herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

Parallel synthesis of substituted imidazoles from 1,2-aminoalcohols

Substituted imidazoles can be prepared efficiently from cyclic or acyclic 1,2-aminoalcohols via a four-step procedure involving acylation of the amine, oxidation of the alcohol, imine formation and cyclization. Examples are presented and the methodology i