5012-76-0Relevant articles and documents
Synthesis of 3-substituted-4(3H)-quinazolinones via HATU-mediated coupling of 4-hydroxyquinazolines with amines
Xiao, Zili,Yang, Michael G.,Li, Peng,Carter, Percy H.
supporting information; experimental part, p. 1421 - 1424 (2009/09/05)
A novel synthesis of 3-substituted 4(3H)-quinazolinones via HATU-mediated coupling of 4-hydroxyquinazolines with primary amines has been developed. Under mild reaction conditions, the products were achieved in good yield from commercially available starti
Superbase catalysis of oxazolidin-2-one ring formation from carbon dioxide and prop-2-yn-1-amines under homogeneous or heterogenous conditions
Costa, Mirco,Chiusoli, Gian Paolo,Taffurelli, Davide,Dalmonego, Giulio
, p. 1541 - 1546 (2007/10/03)
N-alkyl-substituted prop-2-yn-1-amines and N-tri-, tetra- and penta-alkyl-substituted guanidines or other strong organic bases assemble under the action of carbon dioxide to afford carbamates, from which methyleneoxazolidinones 2 are formed by ring closure. If alkyl or cycloalkyl chains of appropriate length are present in the guanidines the reaction readily occurs under heterogenous conditions without solvent.