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501331-02-8

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501331-02-8 Usage

Description

Butanoic acid, 2-[[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]Methyl]-3-Methyl-, (2R)-, commonly known as Ramatroban, is a chemical compound with significant medicinal properties. It functions as an antagonist of the thromboxane A2 receptor, which is instrumental in mediating inflammation and airway constriction. Ramatroban's anti-inflammatory and bronchodilator effects make it a potent therapeutic agent for respiratory conditions such as allergic rhinitis and asthma.

Uses

Used in Pharmaceutical Industry:
Ramatroban is utilized as a medication for the treatment of allergic rhinitis and asthma due to its ability to inhibit the effects of thromboxane, a substance that triggers inflammation and constriction of the airways. Its efficacy in reducing symptoms associated with these conditions makes it a valuable treatment option for patients suffering from respiratory issues.
Used in Allergy Management:
As an antagonist of the thromboxane A2 receptor, Ramatroban is employed in allergy management to alleviate symptoms caused by allergic reactions. Its anti-inflammatory properties help in reducing inflammation, while its bronchodilator effects facilitate easier breathing for individuals with allergic rhinitis.
Used in Asthma Treatment:
In the context of asthma treatment, Ramatroban serves as a crucial component in managing the disease by counteracting the constrictive effects of thromboxane on the airways. This allows for improved lung function and reduced severity of asthma symptoms, providing relief to patients with this chronic respiratory condition.

Check Digit Verification of cas no

The CAS Registry Mumber 501331-02-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,1,3,3 and 1 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 501331-02:
(8*5)+(7*0)+(6*1)+(5*3)+(4*3)+(3*1)+(2*0)+(1*2)=78
78 % 10 = 8
So 501331-02-8 is a valid CAS Registry Number.

501331-02-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-2-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)-3-methylbutanoic acid

1.2 Other means of identification

Product number -
Other names (2R)-2-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]-3-methylbutanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:501331-02-8 SDS

501331-02-8Downstream Products

501331-02-8Relevant articles and documents

Synthesis and biological evaluation of gramicidin S-inspired cyclic mixed α/β-peptides

Van Der Knaap, Matthijs,Basalan, Fatih,Van De Mei, Henny C.,Busscher, Henk J.,Van Der Marel, Gijsbert A.,Overkleeft, Herman S.,Overhand, Mark

, p. 2494 - 2506 (2013/01/16)

Via a Mannich reaction involving a dibenzyliminium species and the titanium enolates of Evans' chiral acylated oxazolidinones the β2-amino acids (R)- and (S)-Fmoc-β2homovaline and (R)-Fmoc- β2homoleucine are synthesized. T

Enantioselective synthesis of beta-amino acids using hexahydrobenzoxazolidinones as chiral auxiliaries

Reyes-Rangel, Gloria,Jimenez-Gonzalez, Erika,Olivares-Romero, Jose Luis,Juaristi, Eusebio

experimental part, p. 2839 - 2849 (2009/06/18)

A practical synthetic route for the asymmetric synthesis of β2-amino acids is described. In the first step, the procedure involves the N-acylation of readily available, enantiopure hexahydrobenzoxazolidinone (4R,5R)-1 with 3-methylbutanoyl chloride 2, 4-methylpentanoic acid 3, and 3-(1-tert-butoxycarbonyl)-1H-indol-3-yl)propanoic acid 4 to afford derivatives 5a, 5b, and 5c, respectively, which were alkylated with high diastereoselectivity by means of reaction between their sodium enolates and benzyl bromoacetate. Removal of the chiral auxiliary from the alkylated products followed by hydrogenation and hydrolysis gave β2-amino acids (S)-10a, (S)-10b, and (S)-10c, which were N-protected with Fmoc. Enantiomeric (R)-10a-c were similarly prepared from the isomeric hexahydrobenzoxazolidinone (4S,5S)-1; thus, the route presented here provides access to both enantiomers of valuable highly enantioenriched β2-amino acids.

Preparation of N-Fmoc-Protected β2- and β3-Amino Acids and Their Use as Building Blocks for the Solid-Phase Synthesis of β-Peptides

Guichard, Gilles,Abele, Stefan,Seebach, Dieter

, p. 187 - 206 (2007/10/03)

N-Fmoc-Protected (Fmoc = (9H-fluoren-9-ylmethoxy)carbonyl) β-amino acids are required for an efficient synthesis of β-oligopeptides on solid support. Enantiomerically pure Fmoc-β3-amino acids (β3: side chain and NH2 at C(3)(=C(β))) were prepared from Fmoc-protected (S)- and (R)-α-amino acids with aliphatic, aromatic, and functionalized side chains, using the standard or an optimized Arndt-Eistert reaction sequence. Fmoc-β2-Amino acids (β2 side chain at C(2), NH2 at C(3)(=C(β))) configuration bearing the side chain of Ala, Val, Leu, and Phe were synthesized via the Evans' chiral auxiliary methodology. The target β3-heptapeptides 5-8, a β3- pentadecapeptide 9 and a β2-heptapeptide 10 were synthesized on a manual solid-phase synthesis apparatus using conventional solid-phase peptide synthesis procedures (Scheme 3). In the case of β3-peptides, two methods were used to anchor the first β-amino acid: esterification of the ortho-chlorotrityl chloride resin with the first Fmoc-β-amino acid 2 (Method I, Scheme 2) or acylation of the 4-(benzyloxy)benzyl alcohol resin (Wang resin) with the ketene intermediates from the Wolff rearrangement of amino-acid-derived diazo ketone 1 (Method II, Scheme 2). The former technique provided better results, as exemplified by the synthesis of the heptapeptides 5 and 6 (Table 2). The intermediate from the Wolff rearrangement of diazo ketones 1 was also used for sequential peptide-bond formation on solid support (synthesis of the tetrapeptides 11 and 12). The CD spectra of the β2- and β3-peptides 5, 9. and 10 show the typical pattern previously assigned to an (M) 31 helical secondary structure (Fig.). The most intense CD absorption was observed with the pentadecapeptide 9 (strong broad negative Cotton effect at ca. 213 nm); compared to the analogous heptapeptide 5, this corresponds to a 2.5 fold increase in the molar ellipticity per residue!

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