501346-96-9Relevant academic research and scientific papers
One-pot gold-catalyzed synthesis of azepino[1,2-a]indoles
Cera, Gianpiero,Piscitelli, Stefano,Chiarucci, Michel,Fabrizi, Giancarlo,Goggiamani, Antonella,Ramón, Rubén S.,Nolan, Steven P.,Bandini, Marco
supporting information, p. 9891 - 9895 (2012/10/29)
Indoles from scratch: A gold(I)/N-heterocyclic carbene complex (IPr=1,3-di(isopropylphenyl)imidazol-2-ylidene) was found to be particularly effective as a catalyst, enabling the one-pot synthesis of tricyclic azepinoindoles by an unprecedented cascade reaction. Readily available substrates, high chemoselectivity, good yields, and water as the only stoichiometric by-product are some of the main advantages of this method. Copyright
Intramolecular Pd-mediated processes of amino-tethered aryl halides and ketones: Insight into the ketone α-arylation and carbonyl-addition dichotomy. A new class of four-membered azapalladacycles
Sole, Daniel,Vallverdu, Lluis,Solans, Xavier,Font-Bardia, Merce,Bonjoch, Josep
, p. 1587 - 1594 (2007/10/03)
An exploration of the scope and limitations of Pd(O)-catalyzed intramolecular coupling reactions of amino-tethered aryl halides and ketones has been conducted. Two different and competitive reaction pathways starting from ω-(2-haloanilino) alkanones, enolate arylation and addition to the carbonyl group, have been observed, while ω-(2-halobenzylamino) alkanones exclusively underwent the enolate arylation process. The dichotomy between ketone α-arylation and carbonyl-addition in the reactions of ω-(2-haloanilino) alkanones has been rationalized by the intermediacy of unprecedented four-membered azapalladacycles, from which X-ray data and chemical behavior are reported.
