501356-76-9Relevant academic research and scientific papers
Redox-switchable phase tags - Facile Mitsunobu reactions using ferrocenyl-tagged triphenylphosphine
Fleckenstein, Christoph A.,Plenio, Herbert
, p. 1058 - 1062 (2006)
The use of redox-switched phase tags in ferrocenyl-substituted triphenylphosphine combined with DBAD (di-tert-butyl azodicarboxylate) allows high yield (> 90%) Mitsunobu transformations without the need for the Chromatographic purification of the products. The redox-switchable phosphine can be easily synthesized in two steps from 4-bromoaniline, ferrocene and chlorodiphenylphosphine. It is separated from the reaction mixture by oxidation with iron(III) chloride and can be recycled efficiently by reductive treatment.
